World Health Organization estimates that one in eight person die from air pollution.
In addition to elucidating protein functions, structural genomics can be used to identify novel protein folds and potential targets for drug discovery.
With many genomes now sequenced, computational annotation methods to characterize genes and proteins from their sequence are increasingly important.
The Bio Sapiens Network has developed tools to address all stages of this process, and here we review progress in the automated prediction of protein function based on protein sequence and structure.
The good news is that methods for predicting structure from sequence can now produce good models for a substantial fraction of the protein space .
Many proteins of known structure are not yet functionally characterized and their number is increasing.