Antihistamines for Hives (Urticaria)Oral antihistamines are the main treatment for hives.
Newer, low-sedating antihistamines, such as Zyrtec or Claritin, are preferred over the older, sedating antihistamines such as Benadryl or Atarax.
Antihistamines are inhibitors of histamine receptors. H1-antihistamines, inhibit competitively H1 receptors and the corresponding effects i. They do not inhibit antigen/antibodies reactions, nor histamine release, they inhibit H1 effects.
H1-antihistamines have been used for more than fifty years in treating various allergic manifestations. H1-antihistamines which penetrate into brain elicit, by inhibiting stimulant effect of histamine, drowsiness.
Their main benefit is they primarily affect peripheral histamine receptors and therefore are less sedating.
However, high doses can still induce drowsiness through acting on the central nervous system.
This leaflet answers some common questions about POLARAMINE.
Itching, sneezing, and inflammatory responses are suppressed by antihistamines that act on H1-receptors.
Oral antihistamines can also help treat the symptoms of eye allergies.
Antihistamines are also available as nasal sprays for the treatment of allergic rhinitis (nasal allergies) and as eye drops for the treatment of allergic conjunctivitis (eye allergies).
In addition, each compound can have or not have parallel properties, antimuscarinic effects for example.
This distinction between generations must be taken with caution because a product considered as non sedative or not antimuscarinic can, in certain circumstances, large doses or particular susceptibility of the patient ,have these effects.