The 38-year-old American star, who played the prison medic Sara Tancredi in the drama, is currently in negotiations to reprise her role in the upcoming reboot.
She admitted in a recent interview that she would love to come back, but it is all dependent on schedules as she is working on another show at the moment.
Fox Chairman Gary Newman said: “It’s going to bring back both brothers, [played by] Wentworth Miller and Dominic Purcell.” CEO Dana Walden added: “I would describe it as a bit of a sequel.
It picks up the characters several years after we left them in the last season of the show. Some of the iconic characters from that show will be back.
Luke Macfarlane and Wentworth Miller reportedly dated from 2007 to 2008.
He’ll be joined by Dominic Purcell, who has also been confirmed for the revival, while Robert Knepper - better known to most as hardened inmate and villain T-Bag - is also in talks to feature in the fifth season.
Sharing details of the show’s return, co-chairman of US broadcaster Fox, Dana Walden, said last year: "I would describe it as a bit of a sequel.
It picks up the characters several years after we left them in the last season of the show." Prison Break ran for four seasons from 20 and followed Michael attempts to break his brother out of jail after he was framed for a crime he didn't commit and sentenced to death.
Fox are yet to announce an official air date, although its believed the Wentworth Miller reboot will arrive on screens in early 2017.
I don’t think [exec producer] Paul [Scheuring] knows exactly where he’s going over the 10-episode arc, but it definitely will address some questions that were set up at the end of the series for a new audience.” “It’s going to take a little bit of a detour from where we left off, but it should feel very satisfying and event-ized.