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Substantial evidence demonstrates both nicotine's addiction liability and its cognition-enhancing effects.
However, the neurobiological mechanisms underlying nicotine's impact on brain function and behavior remain incompletely understood.
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This research spans from receptor-level PET and SPECT studies demonstrating nicotine occupancy at nicotinic acetylcholine receptors (n ACh Rs) and upregulation of n ACh Rs induced by chronic smoking; through nicotine's interactions with the mesocorticolimbic dopamine system believed to mediate nicotine's reinforcing effects leading to dependence; to functional activity and connectivity f MRI studies documenting nicotine's complex behavioral and cognitive effects manifest by its actions on large-scale brain networks engaged both during task performance and at rest.
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